fetzima_logo_productWhat is Fetzima?

Fetzima (levomilnacipran) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI). Levomilnacipran affects chemicals in the brain that may become unbalanced and cause depression.

Fetzima is used to treat major depressive disorder.

A similar medicine called milnacipran (Savella) is used to treat a chronic pain disorder called fibromyalgia. Fetzima should not be used to treat fibromyalgia.

Fetzima may also be used for purposes not listed in this medication guide.

Important information about Fetzima

You should not use Fetzima if you have untreated or uncontrolled narrow-angle glaucoma.

Do not use Fetzima if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not use an MAO inhibitor within 7 days after you stop taking Fetzima.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Fetzima. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not give this medication to anyone under 18 years old without medical advice.

Before taking Fetzima

Do not use Fetzima if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not use an MAO inhibitor within 7 days after you stop taking Fetzima.

You should not use Fetzima if you are allergic to levomilnacipran or milnacipran (Savella), or if you have untreated or uncontrolled narrow-angle glaucoma.

To make sure Fetzima is safe for you, tell your doctor if you have:

heart disease, high blood pressure, heart rhythm disorder;
a bleeding or blood clotting disorder such as hemophilia;
bipolar disorder (manic depression);
seizures or epilepsy;
kidney disease;
low levels of sodium in your blood);
bladder obstruction or other urination problems;
if you drink large amounts of alcohol; or
if you take a diuretic (“water pill”) or use migraine headache medicine.
You may have thoughts about suicide while taking this medication, especially if you are younger than 24 years old. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. It is not known whether Fetzima will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

See also: Fetzima pregnancy and breastfeeding warnings (in more detail)

It is not known whether levomilnacipran passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Older adults may be more sensitive to the side effects of this medication.

Do not give this medication to anyone under 18 years old without medical advice.

How should I take Fetzima?

Take Fetzima exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Fetzima with or without food.

Do not crush, chew, break, or open a Fetzima capsule. Swallow it whole.

Your blood pressure and heart rate will need to be checked often.

Do not stop using Fetzima suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor’s instructions about tapering your dose.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Fetzima Dosing Information

Usual Adult Dose for Depression:

Initial dose: 20 mg orally once a day for 2 days then increase to 40 mg orally once a day. Dose may be increased in increments of 40 mg at intervals of 2 or more days based on tolerability and efficacy.
Maintenance dose: 40 to 120 mg orally once a day
Maximum dose: 120 mg orally once a day

Approved indication: Major depressive disorder (MDD)

What should I avoid while taking Fetzima?

Avoid drinking alcohol. It may raise your blood levels of Fetzima.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with Fetzima may cause you to bruise or bleed easily.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

See also: Fetzima and alcohol (in more detail)

Fetzima side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Fetzima: skin rash or hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

painful or difficult urination;
seizure (convulsions);
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
pounding heartbeats or fluttering in your chest;
high levels of serotonin in the body–agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
low levels of sodium in the body–headache, confusion, slurred speech, severe weakness, muscle cramps, loss of coordination, feeling unsteady, fainting, shallow breathing;
Common Fetzima side effects may include:

nausea, vomiting, constipation;
blurred vision;
increased sweating;
fast heart rate; or
decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Fetzima side effects (in more detail)

What other drugs will affect Fetzima?

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking Fetzima with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Fetzima, especially:

tryptophan (sometimes called L-tryptophan);
any other antidepressant;
a blood thinner (warfarin, Coumadin); or
medicine to treat anxiety or mental illness–buspirone, lithium, and others.
This list is not complete. Other drugs may interact with levomilnacipran, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Google Facebook Twitter Print Email Add to Mednotes
Next Page → Side Effects
More about Fetzima (levomilnacipran)

Side Effects
Pregnancy Warnings
Drug Images
Drug Interactions
Support Group
0 Reviews – Add your own review/rating
Consumer resources

Fetzima extended-release capsules (Basic Reading)
Fetzima (Advanced Reading)
Compare with other treatments for:

Where can I get more information?

Your pharmacist can provide more information about Fetzima.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Fetzima only for the indication prescribed.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2014 Cerner Multum, Inc. Version: 1.01. Revision Date: 2013-09-06, 12:39:38 PM.


8 responses to “Fetzima

  1. This is worse than effexor by far to get off of. It it the absolute worst thing. I am ill, bloated, severe headaches, baker cysts in knee (no arthritis) fatigued, irritable, nauseous, diarrhea, weepy. This is a horrible chemical. Please do not use it!


    • I’ve actually stopped taking fetzima a while ago. Partially from insurance not covering it when I switched companies…secondly was finding the product itself was a challenge.

      I can say personally, I didn’t experience any of those withdrawal symptoms you speak of…

      But as all 8 million different legal drugs on the market, they all act differently with everyone. Some positive, sadly some negative.
      I’m sorry it didn’t help you. I thought it was helping me when I was taking it, but I’ve also changed my meds so many times over the last 25 years my body doesn’t seem to have the issues that most people experience.


    • I am feeling extremely bloated, headache and just over all ill. I’m taking 20 mgs of Fetzima.
      I’m half tempted to stop but I really know my pdoc.
      Would be very unhappy.
      I’ve tried everything, even Brintellix and that didn’t work…….. I don’t know how much longer I can hold out honestly sick and tired of trying. .
      Maybe no hope for me…


    • I came off 120mg of Fetzima about three or four days ago and have major dizziness and feel very sluggish. Luckily no flu-like symptoms or nightmares yet, but I am having very vivid dreams about alcohol & drugs (I’m a recovering alcoholic and addict).

      Fetzima’s “symptoms of discontinuance” are worse than Effexor’s for me as well. However, I didn’t realize what was happening when I went off Effexor, which made that pretty scary.


  2. Hey there just wanted to give you a quick heads up. The words in your content seem to be running off the screen in Opera. I’m not sure if this is a formatting issue or something to do with internet browser compatibility but I thought I’d post to let you know. The design look great though! Hope you get the issue resolved soon. Thanks


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s